PPARG

PPARG
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP, 2HWQ, 2HWR, 2I4J, 2I4P, 2I4Z, 2OM9, 2P4Y, 2POB, 2PRG, 2Q59, 2Q5P, 2Q5S, 2Q61, 2Q6R, 2Q6S, 2Q8S, 2QMV, 2VSR, 2VST, 2VV0, 2VV1, 2VV2, 2VV3, 2VV4, 2XKW, 2YFE, 2ZK0, 2ZK1, 2ZK2, 2ZK3, 2ZK4, 2ZK5, 2ZK6, 2ZNO, 2ZVT, 3ADS, 3ADT, 3ADU, 3ADV, 3ADW, 3ADX, 3AN3, 3AN4, 3B0Q, 3B0R, 3B1M, 3B3K, 3BC5, 3CDP, 3CDS, 3CS8, 3CWD, 3D6D, 3DZU, 3DZY, 3E00, 3ET0, 3ET3, 3FEJ, 3FUR, 3G9E, 3GBK, 3H0A, 3HO0, 3HOD, 3IA6, 3K8S, 3KMG, 3LMP, 3NOA, 3OSI, 3OSW, 3PBA, 3PO9, 3PRG, 3QT0, 3R5N, 3R8A, 3R8I, 3S9S, 3SZ1, 3T03, 3TY0, 3U9Q, 3V9T, 3V9V, 3V9Y, 3VJH, 3VJI, 3VN2, 3VSO, 3VSP, 3WJ4, 3WJ5, 3WMH, 3X1H, 3X1I, 4A4V, 4A4W, 4CI5, 4E4K, 4E4Q, 4EM9, 4EMA, 4F9M, 4FGY, 4HEE, 4JAZ, 4JL4, 4L96, 4L98, 4O8F, 4OJ4, 4PRG, 4PVU, 4PWL, 4R2U, 4R6S, 4XLD, 4R06, 4Y29, 4XTA, 4XUM, 4YT1, 4XUH, 5F9B, 5AZV
Dynodwyr
Cyfenwau	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5
Dynodwyr allanol	OMIM: 601487 HomoloGene: 7899 GeneCards: PPARG
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • alpha-actinin binding; • chromatin binding; • prostaglandin receptor activity; • core promoter sequence-specific DNA binding; • enzyme binding; • protein phosphatase binding; • metal ion binding; • arachidonic acid binding; • nuclear receptor coactivator activity; • steroid hormone receptor activity; • sequence-specific DNA binding; • identical protein binding; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • double-stranded DNA binding; • protein C-terminus binding; • zinc ion binding; • peptide binding; • protein self-association; • retinoid X receptor binding; • protein heterodimerization activity; • DNA binding domain binding; • LBD domain binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor binding; • estrogen receptor binding; • E-box binding; • GO:0000975 transcription cis-regulatory region binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • fatty acid binding; • lipid binding; • signaling receptor activity;
Cydrannau o'r gell	• cytosol; • RNA polymerase II transcription regulator complex; • perinuclear region of cytoplasm; • cytoplasm; • cnewyllyn cell; • intracellular membrane-bounded organelle; • nucleoplasm; • GO:0009327 protein-containing complex;
Prosesau biolegol	• negative regulation of cell population proliferation; • epithelial cell differentiation; • negative regulation of smooth muscle cell proliferation; • positive regulation of oligodendrocyte differentiation; • transcription, DNA-templated; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • response to lipid; • placenta development; • cellular response to vitamin E; • negative regulation of interferon-gamma-mediated signaling pathway; • negative regulation of sequestering of triglyceride; • regulation of fat cell differentiation; • cellular response to retinoic acid; • glucose homeostasis; • negative regulation of collagen biosynthetic process; • cellular response to hyperoxia; • response to estrogen; • regulation of cholesterol transporter activity; • regulation of circadian rhythm; • negative regulation of telomerase activity; • GO:0072468 signal transduction; • cellular response to insulin stimulus; • monocyte differentiation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • regulation of blood pressure; • positive regulation of apoptotic process; • positive regulation of fat cell differentiation; • negative regulation of cholesterol storage; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of cell growth; • GO:0045996 negative regulation of transcription, DNA-templated; • cellular response to prostaglandin stimulus; • animal organ regeneration; • positive regulation of DNA-binding transcription factor activity; • lipoprotein transport; • response to metformin; • heart development; • response to cold; • negative regulation of acute inflammatory response; • fatty acid oxidation; • lipid homeostasis; • transcription initiation from RNA polymerase II promoter; • response to vitamin A; • innate immune response; • response to retinoic acid; • cell maturation; • cell fate commitment; • peroxisome proliferator activated receptor signaling pathway; • proses rythmig; • response to mechanical stimulus; • long-chain fatty acid transport; • lipid metabolism; • response to caffeine; • positive regulation of fatty acid oxidation; • response to immobilization stress; • positive regulation of phagocytosis, engulfment; • negative regulation of pancreatic stellate cell proliferation; • response to starvation; • GO:1904578 response to organic cyclic compound; • regulation of lipid metabolic process; • steroid hormone mediated signaling pathway; • response to organic substance; • response to nutrient; • cellular response to prostaglandin E stimulus; • GO:1901227 negative regulation of transcription by RNA polymerase II; • white fat cell differentiation; • negative regulation of macrophage derived foam cell differentiation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • G protein-coupled receptor signaling pathway; • macrophage derived foam cell differentiation; • positive regulation of DNA binding; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of angiogenesis; • negative regulation of blood vessel endothelial cell migration; • pri-miRNA transcription by RNA polymerase II; • GO:1905617 negative regulation of gene silencing by miRNA; • cellular response to low-density lipoprotein particle stimulus; • positive regulation of vascular associated smooth muscle cell apoptotic process; • negative regulation of vascular endothelial cell proliferation; • negative regulation of vascular associated smooth muscle cell proliferation; • fatty acid metabolic process; • multicellular organism development; • hormone-mediated signaling pathway; • cell differentiation; • intracellular receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	5468
	n/a
	ENSG00000132170
	n/a
	P37231
	n/a
NM_005037; NM_015869; NM_138711; NM_138712; NM_001330615;
	NM_001354666; NM_001354667; NM_001354668; NM_001354669; NM_001354670; NM_001374261; NM_001374262; NM_001374263; NM_001374264; NM_001374265; NM_001374266
	n/a
NP_001317544; NP_005028; NP_056953; NP_619725; NP_619726;
	NP_001341595; NP_001341596; NP_001341597; NP_001341598; NP_001341599; NP_001361190; NP_001361191; NP_001361192; NP_001361193; NP_001361194; NP_001361195
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPARG yw PPARG a elwir hefyd yn Peroxisome proliferator-activated receptor gamma a Peroxisome proliferator activated receptor gamma (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p25.2.^[2]

[1] "Human PubMed Reference:".

[2] PPARG - Cronfa NCBI

[1]

[2]

PPARG

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